Phase 1 and 2 CCNA Publications including Sex and Gender analysis

PHASE 1

Curtis, A. F., Masellis, M., Hsiung, G. R., Moineddin, R., Zhang, K., Au, B., Millett, G., Mackenzie, I., Rogaeva, E. & Tierney, M. C. (2017) Sex differences in the prevalence of genetic mutations in FTD and ALS: A meta-analysis. Neurology, 89(15):1633-1642. doi: 10.1212/WNL.0000000000004494 

Kim, J., E. Fischer, C., A. Schweizer, T., & G. Munoz, D. (2017). Gender and pathology-specific effect of Apolipoprotein E genotype on psychosis in Alzheimer’s disease. Current Alzheimer Research, 14(8), 834-840.

Tierney, M. C., Curtis, A. F., Chertkow, H., & Rylett, R. J. (2017). Integrating sex and gender into neurodegeneration research: A six-component strategy. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 3(4), 660-667. 

McDermott, K. L., McFall, G. P., Andrews, S. J., Anstey, K. J., & Dixon, R. A. (2017). Memory resilience to Alzheimer’s genetic risk: Sex effects in predictor profiles. Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 72(6), 937-946.

Baines, N., Au, B., Rapoport, M. J., Naglie, G., & Tierney, M. C. (2018). Meta-analysis of driving cessation and dementia: does sex matter?. The Journals of Gerontology: Series B, 73(7), 1185-1189.

Armstrong, J. J., Godin, J., Launer, L. J., White, L. R., Mitnitski, A., Rockwood, K., & Andrew, M. K. (2016). Changes in frailty predict changes in cognition in older men: the Honolulu-Asia aging study. Journal of Alzheimer’s Disease, 53(3), 1003-1013.

PHASE 2

2019-2020

  1. Gervais, N. J., Au, A., Almey, A., Duchesne, A., Gravelsins, L., Brown, A., ... & Einstein, G. (2020). Cognitive markers of dementia risk in middle-aged women with bilateral salpingo-oophorectomy prior to menopause. Neurobiology of aging, 94, 1-6.

  2. D’Amico, D., Parrott, M. D., Greenwood, C. E., Ferland, G., Gaudreau, P., Belleville, S., ... & Fiocco, A. J. (2020). Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study. Nutrition Journal, 19(1), 58.

  3. 3. Ursenbach, J., O’Connell, M. E., Kirk, A., & Morgan, D. (2020). Evidence for measurement bias of the short form health survey based on sex and metropolitan influence zone in a secondary care population. Health and Quality of Life Outcomes, 18(1), 91. 

  4. Sourial, N., Vedel, I., Godard‐Sebillotte, C., Etches, J., Arsenault‐Lapierre, G., & Bronskill, S. E. (2020). Sex differences in dementia primary care performance and health service use: A population‐based study. Journal of the American Geriatrics Society, 68(5), 1056-1063. 

  5.  McFall, G. P., Bäckman, L., & Dixon, R. A. (2019). Nuances in Alzheimer’s genetic risk reveal differential predictions of non-demented memory aging trajectories: selective patterns by APOE genotype and sex. Current Alzheimer Research, 16(4), 302-315.

    2020-2021

  6. Le Guen, Y., Napolioni, V., Belloy, M. E., Yu, E., Krohn, L., Ruskey, J. A., ... & Greicius, M. D. (2021). Common X‐chromosome variants are associated with Parkinson disease risk. Annals of neurology, 90(1), 22-34.

  7. Kapadia, M., Mian, M. F., Ma, D., Hutton, C. P., Azam, A., Narkaj, K., ... & Sakic, B. (2021). Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD mice. Alzheimer's Research & Therapy, 13(1), 30.

  8. Pentz, R., Iulita, M. F., Mikutra-Cencora, M., Ducatenzeiler, A., Bennett, D. A., & Cuello, A. C. (2021). A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology. Neurobiology of disease, 148, 105150.

  9. Wang T, Therriault J, Benedet AL, Pascoal TA, Savard M, Ashton NJ, Chamoun M, Tissot C, Lussier F, Kang MS, Bezgin G, Fernandes-Arias J, Massarweh G, Vitali P, Zetterberg H, Blennow K, Saha-Chaudhuri P, Soucy JP, Gauthier S, Rosa-Neto P. "Interactive rather than Independent Effect of APOEε4 and Sex Potentiates Tau Deposition in Women. (2021). Brain Communications, Volume 3, Issue 2, 2021, fcab126, https://doi.org/10.1093/braincomms/fcab126

  10. Kozyrev, N., Albers, S., Yang, J., Prado, V. F., Prado, M. A., Fonseca, G. J., ... & Dekaban, G. A. (2020). Infiltrating hematogenous macrophages aggregate around β-amyloid plaques in an age-and sex-dependent manner in a mouse model of Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 79(11), 1147-1162.

  11. D’Amico, D., Parrott, M. D., Greenwood, C. E., Ferland, G., Gaudreau, P., Belleville, S., ... & Fiocco, A. J. (2020). Sex differences in the relationship between dietary pattern adherence and cognitive function among older adults: findings from the NuAge study. Nutrition Journal, 19(1), 58.

  12. Anstey, K. J., Peters, R., Mortby, M. E., Kiely, K. M., Eramudugolla, R., Cherbuin, N., ... & Dixon, R. A. (2021). Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years. Scientific Reports, 11(1), 7710.

  13. Drouin, S. M., McFall, G. P., & Dixon, R. A. (2020). In multiple facets of subjective memory decline sex moderates memory predictions. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 12(1), e12089.

  14. Bohn, L., Zheng, Y., McFall, G. P., & Dixon, R. A. (2021). Portals to frailty? Data-driven analyses detect early frailty profiles. Alzheimer's Research & Therapy, 13(1), 1.

  15. Published a review of age, sex and genetic CYP polymorphisms on the pharmacokinetics of anticholinergic medications in Pharmacology Research & Perspectives - Shanna C Trenaman, Susan K Bowles, Melissa K Andrew, Kerry Goralski. (2020). The Effect of Sex, Age and Genetic Polymorphisms of CYP Enzymes on the Pharmacokinetics of Anticholinergic Drugs. Pharmacology Research & Perspectives. 9(3). https://doi.org/10.1002/prp2.775

  16. Sourial, N., Vedel, I., Godard‐Sebillotte, C., Etches, J., Arsenault‐Lapierre, G., & Bronskill, S. E. (2020). Sex differences in dementia primary care performance and health service use: A population‐based study. Journal of the American Geriatrics Society, 68(5), 1056-1063.

    2022-2023

  17. Tang, X., Gonzalez‐Latapi, P., Marras, C., Visanji, N. P., Yang, W., Sato, C., ... & Zhang, M. (2022). Epigenetic clock acceleration is linked to age at onset of Parkinson's disease. Movement Disorders, 37(9), 1831-1840.

  18. Domenighetti, C., Douillard, V., Sugier, P. E., Sreelatha, A. A. K., Schulte, C., Grover, S., ... & Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage‐PD) Consortium. (2022). The interaction between HLA‐DRB1 and smoking in Parkinson's disease revisited. Movement Disorders, 37(9), 1929-1937.

  19. Couto, B., Martinez‐Valbuena, I., Lee, S., Alfradique‐Dunham, I., Perrin, R. J., Perlmutter, J. S., ... & Kovacs, G. G. (2022). Protracted course progressive supranuclear palsy. European journal of neurology, 29(8), 2220-2231.

  20. Bally, J. F., Zhang, M., Dwosh, E., Sato, C., Rutka, J., Lang, A. E., & Rogaeva, E. (2022). Genomic study of a large family with complex neurological phenotype including hearing loss, imbalance and action tremor. Neurobiology of Aging, 113, 137-142.

  21. Domenighetti, C., Sugier, P. E., Ashok Kumar Sreelatha, A., Schulte, C., Grover, S., Mohamed, O., ... & Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage‐PD) Consortium. (2022). Dairy intake and Parkinson's disease: a Mendelian randomization study. Movement Disorders, 37(4), 857-864.

  22. Erkamp, N. A., Sneideris, T., Ausserwöger, H., Qian, D., Qamar, S., Nixon-Abell, J., ... & Knowles, T. P. (2023). Spatially non-uniform condensates emerge from dynamically arrested phase separation. Nature Communications, 14(1), 684.

  23. Volkmar, N., Gawden‐Bone, C. M., Williamson, J. C., Nixon‐Abell, J., West, J. A., St George‐Hyslop, P. H., ... & Lehner, P. J. (2022). Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2. The EMBO Journal, 41(19), e110777.

  24. Senkevich, K., Zorca, C. E., Dworkind, A., Rudakou, U., Somerville, E., Yu, E., ... & Gan-Or, Z. (2023). GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson’s disease. Brain, 146(5), 1859-1872.

  25. Krohn, L., Heilbron, K., Blauwendraat, C., Reynolds, R. H., Yu, E., Senkevich, K., ... & Gan-Or, Z. (2022). Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects. Nature communications, 13(1), 7496.

  26. Morys, F., Yu, E., Shishikura, M., Paquola, C., Vainik, U., Nave, G., ... & Dagher, A. (2023). Neuroanatomical correlates of genetic risk for obesity in children. Translational Psychiatry, 13(1), 1.

  27. Parlar, S. C., Grenn, F. P., Kim, J. J., Baluwendraat, C., & Gan‐Or, Z. (2023). Classification of GBA1 variants in Parkinson's disease: the GBA1‐PD browser. Movement Disorders, 38(3), 489-495.

  28. Duchaine, C. S., Fiocco, A. J., Carmichael, P. H., Cunnane, S. C., Plourde, M., Lampuré, A., ... & Laurin, D. (2022). Serum ω-3 fatty acids and cognitive domains in community-dwelling older adults from the NuAge Study: exploring the associations with other fatty acids and sex. The Journal of Nutrition, 152(9), 2117-2124.

  29. Obomsawin, A., D’Amico, D., & Fiocco, A. J. (2022). The association between Mediterranean diet adherence and allostatic load in older adults. Psychoneuroendocrinology, 143, 105840.

  30. Durrani, R., Badhwar, A., Bhangu, J., Ganesh, A., Black, S. E., Barber, P. A., ... & Smith, E. E. (2022). Vascular brain lesions, cognitive reserve, and their association with cognitive profile in persons with early-stage cognitive decline. Journal of Alzheimer's Disease Reports, 6(1), 607-616.

  31. Drouin, S. M., McFall, G. P., & Dixon, R. A. (2022). Subjective memory concerns, poor vascular health, and male sex predict exacerbated memory decline trajectories: An integrative data-driven class and prediction analysis. Neuropsychology, 36(2), 128.

  32. Drouin, S. M., McFall, G. P., Potvin, O., Bellec, P., Masellis, M., Duchesne, S., ... & Alzheimer’s Disease Neuroimaging Initiative. (2022). Data-driven analyses of longitudinal hippocampal imaging trajectories: discrimination and biomarker prediction of change classes. Journal of Alzheimer’s Disease, 88(1), 97-115.

  33. Heal, M., McFall, G. P., Vergote, D., Jhamandas, J. H., Westaway, D., & Dixon, R. A. (2022). Bridging integrator 1 (BIN1, rs6733839) and sex are moderators of vascular health predictions of memory aging trajectories. Journal of Alzheimer’s Disease, 89(1), 265-281.

  34. Corriveau-Lecavalier, N., Décarie-Labbé, L., Mellah, S., Belleville, S., & Rajah, M. N. (2022). Sex differences in patterns of associative memory-related activation in individuals at risk of Alzheimer's disease. Neurobiology of Aging, 119, 89-101.

  35. Rivet, L., Tumati, S., Datta, D., Seitz, D. P., Gallagher, D., Herrmann, N., & Lanctôt, K. (2023). The Relationship Between Grey Matter Atrophy and Apathy Severity in Alzheimer's, Parkinson's, and Mixed Dementia: A COMPASS-ND study. The American Journal of Geriatric Psychiatry, 31(3), S98.

  36. Eikelboom, W. S., Pan, M., Ossenkoppele, R., Coesmans, M., Gatchel, J. R., Ismail, Z., ... & Papma, J. M. (2022). Sex differences in neuropsychiatric symptoms in Alzheimer’s disease dementia: a meta-analysis. Alzheimer's research & therapy, 14(1), 48.

  37. Trenaman, S. C., Harding, A., Bowles, S. K., Kirkland, S. A., & Andrew, M. K. (2022). A prescribing cascade of proton pump inhibitors following anticholinergic medications in older adults with dementia. Frontiers in Pharmacology, 13, 878092.

  38. Guan, D. X., Rockwood, K., Smith, E. E., & Ismail, Z. (2022). Sex moderates the association between frailty and mild behavioral impairment. The Journal of Prevention of Alzheimer's Disease, 9(4), 692-700.

  39. Reavis, K. M., Bisgaard, N., Canlon, B., Dubno, J. R., Frisina, R. D., Hertzano, R., ... & Singh, G. (2023). Sex-linked biology and gender-related research is essential to advancing hearing health. Ear and hearing, 44(1), 10-27.

  40. Phillips, N. A., Isler, L., Kabir, R., Hämäläinen, A., Wittich, W., Pichora-Fuller, M. K., & Mick, P. (2022). Hearing and visual acuity predict cognitive function in adults aged 45–85 years: Findings from the baseline wave of the Canadian Longitudinal Study on Aging (CLSA). Psychology and aging, 37(8), 891.

  41. Snowball, E., Fernandez Loughlin, R., Eagleson, H., Barnett, K. M., McLellan, E., O’Connor, D., ... & Bethell, J. (2022). Engagement of people with lived experience of dementia advisory group and cross-cutting program: reflections on the first year. Research involvement and engagement, 8(1), 28.

  42. Bechard, L. E., McGilton, K. S., Middleton, L. E., Chertkow, H., Sivananthan, S., & Bethell, J. (2022). Engaging people with lived experience of dementia in research: perspectives from a multi-disciplinary research network. Canadian Geriatrics Journal, 25(3), 254.

  43. Maclagan, L. C., Wang, X., Emdin, A., Jones, A., Jaakkimainen, R. L., Schull, M. J., ... & Bronskill, S. E. (2022). Visits to the emergency department by community-dwelling people with dementia during the first 2 waves of the COVID-19 pandemic in Ontario: a repeated cross-sectional analysis. Canadian Medical Association Open Access Journal, 10(3), E610-E621.

  44. Gervais, N. J., Gravelsins, L., Brown, A., Reuben, R., Karkaby, L., Baker-Sullivan, E., ... & Einstein, G. (2022). Scene memory and hippocampal volume in middle-aged women with early hormone loss. Neurobiology of Aging, 117, 97-106.

  45. Al-Yawer, F., Pichora-Fuller, M.K., Wittich, W., Mick, P.8, Giroud, N., Rehan, S., and Phillips, N.A. (2023). Sex-specific Interactions Between Hearing and Memory in Older Adults with Mild Cognitive Impairment: Findings from the COMPASS-ND Study. Ear and Hearing. 44(4):p 751-767, DOI: 10.1097/AUD.0000000000001322

    2023-2024

  46. Koblinsky, N. D., Power, K. A., Middleton, L., Ferland, G., & Anderson, N. D. (2023). The role of the gut microbiome in diet and exercise effects on cognition: a review of the intervention literature. The Journals of Gerontology: Series A, 78(2), 195-205.

  47. Koblinsky, N. D., Carmichael, P. H., Belleville, S., Fiocco, A. J., Gaudreau, P., Greenwood, C. E., ... & Ferland, G. (2023). Associations between circulating cardiovascular disease risk factors and cognitive performance in cognitively healthy older adults from the NuAge study. Frontiers in Aging Neuroscience, 15, 1274794.

  48. Trinca, V., & Keller, H. (2023). Nutrition Risk is Associated with 3-Year strength and performance indicators among older adults in the Canadian longitudinal study on aging. The Journal of nutrition, health and aging, 27(10), 868-877.

  49. D'Amico, D., Alter, U., Laurin, D., Ferland, G., & Fiocco, A. J. (2024). Examining a Healthy Lifestyle as a Moderator of the Relationship between Psychological Distress and Cognitive Decline among Older Adults in the NuAge Study. Gerontology, 70(4), 418-428.

  50. Trinca, V., Anderson, N. D., Fiocco, A. J., Ferland, G., Laurin, D., & Keller, H. H. (2023). Nutrition risk and cognitive performance in community-living older adults without cognitive impairment: a cross-sectional analysis of the Canadian Longitudinal Study on Aging. Applied Physiology, Nutrition, and Metabolism, 48(12), 896-906.

  51. D’Amico, D., Amestoy, M. E., & Fiocco, A. J. (2024). Psychological stress across the lifespan and cognitive function among older adults: the moderating role of a healthy lifestyle. Canadian Journal on Aging/La Revue Canadienne du Vieillissement, 43(3), 427-437.

  52. Monti, F., Stewart, D., Surendra, A., Alecu, I., Nguyen-Tran, T., Bennett, S. A., & Čuperlović-Culf, M. (2023). Signed Distance Correlation (SiDCo): an online implementation of distance correlation and partial distance correlation for data-driven network analysis. Bioinformatics, 39(5), btad210.

  53. Kapustin, D., Tumati, S., Wong, M., Herrmann, N., Dixon, R. A., Seitz, D., ... & Lanctôt, K. L. (2024). Sex‐specific neuropsychological correlates of apathy and depression across neurodegenerative disorders. International Journal of Geriatric Psychiatry, 39(3), e6080.

  54. Zheng, L., Eramudugolla, R., Cherbuin, N., Drouin, S. M., Dixon, R. A., & Anstey, K. J. (2023). Gender specific factors contributing to cognitive resilience in APOE ɛ4 positive older adults in a population-based sample. Scientific Reports, 13(1), 8037.

  55. Kapustin, D., Tumati, S., Wong, M., Herrmann, N., Dixon, R. A., Seitz, D., ... & Lanctôt, K. L. (2024). Sex‐specific neuropsychological correlates of apathy and depression across neurodegenerative disorders. International Journal of Geriatric Psychiatry, 39(3), e6080.

  56. Light, V., Jones, S. L., Rahme, E., Rousseau, K., de Boer, S., Vermunt, L., ... & Consortium, F. S. (2024). Clinical accuracy of serum neurofilament light to differentiate frontotemporal dementia from primary psychiatric disorders is age-dependent. The American Journal of Geriatric Psychiatry, 32(8), 988-1001.

  57. Mah, J. C., Penwarden, J. L., Pott, H., Theou, O., & Andrew, M. K. (2023). Social vulnerability indices: a scoping review. BMC public health, 23(1), 1253.

  58. Mah, J. C., Godin, J., Stevens, S. J., Keefe, J. M., Rockwood, K., & Andrew, M. K. (2023). Social vulnerability and frailty in hospitalized older adults. Canadian Geriatrics Journal, 26(3), 390.

  59. Scerbe, A., O’Connell, M. E., Astell, A., Morgan, D., Kosteniuk, J., Panyavin, I., ... & Webster, C. (2023). Digital tools for delivery of dementia education for caregivers of persons with dementia: a systematic review and meta-analysis of impact on caregiver distress and depressive symptoms. PLoS One, 18(5), e0283600.

  60. Al-Yawer, F., Pichora-Fuller, M. K., Wittich, W., Mick, P., Giroud, N., Rehan, S., & Phillips, N. A. (2023). Sex-specific interactions between hearing and memory in older adults with Mild Cognitive Impairment: Findings from the COMPASS-ND study. Ear and hearing, 44(4), 751-767.

  61. Arsenault-Lapierre, G., Bui, T., Godard-Sebillotte, C., Kang, N., Sourial, N., Rochette, L., ... & Vedel, I. (2025). Sex Differences in Healthcare Utilization in Persons Living with Dementia Between 2000 and 2017: A Population-Based Study in Quebec, Canada. Journal of aging and health, 37(3-4), 243-254.

  62. Brown, A., Gervais, N. J., Rieck, J., Almey, A., Gravelsins, L., Reuben, R., ... & Einstein, G. (2023). Women’s brain health: midlife ovarian removal affects associative memory. Molecular neurobiology, 60(11), 6145-6159.

  63. Crestol, A., Rajagopal, S., Lissaman, R., LaPlume, A. A., Pasvanis, S., Olsen, R. K., ... & Rajah, M. N. (2023). Menopause status and within-group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females. Journal of Neuroscience, 43(50), 8756-8768.

  64. Subramaniapillai, S., Galea, L. A., Einstein, G., & de Lange, A. M. G. (2024). Sex and gender in health research: intersectionality matters. Frontiers in neuroendocrinology, 72, 101104.

  65. Calvo, N., & Einstein, G. (2023). Steroid hormones: risk and resilience in women’s Alzheimer disease. Frontiers in Aging Neuroscience, 15, 1159435.

  66. Gervais, N. J., Gravelsins, L., Brown, A., Reuben, R., Perovic, M., Karkaby, L., ... & Einstein, G. (2023). Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal. Frontiers in endocrinology, 14, 1265470.

  67. Wood Alexander, M., Wu, C. Y., Coughlan, G. T., Puri, T., Buckley, R. F., Palta, P., ... & Rabin, J. S. (2024). Associations between age at menopause, vascular risk, and 3-year cognitive change in the Canadian longitudinal study on aging. Neurology, 102(9), e209298.